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KMID : 0359720150330030201
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Journal of the Korean Neurological Association
2015 Volume.33 No. 3 p.201 ~ p.205
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An Autopsy Case of Frontotemporal Dementia with Motor Neuron Disease
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Kim Eun-Joo
Oh Eun-Hye
Kim Ki-Tae
Jung Yoo-Ri
Lee Jeong-Hee
Lee Jae-Hyeok
Lee Young-Min
Kim Seong-Jang
Shin Jin-Hong
Shin Myung-Jun
Lee Myung-Jun
Ahn Jae-Woo
Sung Suk
Choi Kyung-Un
Jung Dae-Soo
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Abstract
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Approximately 15% of patients with frontotemporal dementia (FTD) have co-occurring motor neuron disease (MND). FTD-MND cases have frontotemporal lobar degeneration (FTLD)?transactive response DNA-binding protein (TDP) pathology, which is divided into four subtypes (types A, B, C, and D) based on the morphological appearance, cellular location, and distribution of the abnormal TDP inclusions and dystrophic neurites. We report a patient with FTD-MND whose pathological diagnosis was FTLD-TDP type B. This is the first documented autopsy-confirmed case of FTD-MND in Korea.
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KEYWORD
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Frontotemporal dementia, Motor neuron disease, Transactive response DNA-binding protein
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